1The news of her mother's illness caused her immense anguish and she couldn't concentrate on her work.
2The family went through a period of anguish after the loss of their loved one.
3The doctor tried to reassure the patient that the treatment would not cause too much anguish.
4The anguish in her eyes was clear as she talked about her past experiences.
5The novel explores the themes of love, loss, and anguish in a powerful and moving way.